We have built one of the first ever created Spanish text user-level depression classifiers, which was trained with hundreds of Telegram posts and reached high accuracy.
My research
An analysis of the number of women and men working in Science, Technology, Engineering and Mathematics (STEM) who are quoted in the written press in Spain between 2016 and 2020.
We describe the development of a mouse model for a human polymorphism in the serotonin transporter linked to increased anxiety
Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders
A review of epigenetic mechanisms in cognitive and neurodegenerative diseases.
Common Molecules in Memory Formation and Congenital Intellectual Disability: a Role for the RAS-ERK-CREB Pathway in Cognition
In my PhD thesis, I described the role that several molecules within the signalling cascade that activates the transcription factor CREB (cAMP Response Element Binding protein) play in long-term memory formation. In humans and mice, mutations in the genes encoding for several proteins within such molecular cascade result in learning and memory deficits. Awarded an Extraordinary Doctorate Award.
A new mechanism by which environmental enrichment triggers enhanced learning and memory in mice.
Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: differential contribution of p300 and CBP to Rubinstein–Taybi syndrome etiology
Here we validate a new mouse model for a rare human disease called Rubinstein-Taybi syndrome, characterized by skeletal malformations and intellectual disability.
Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory
We discover that an increase of neuronal excitability, triggered by enhanced activity of the transcription factor CREB, boosts simple forms of associative memory.
Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information
Contrary to what would be expected of a molecular intermediary of memory formation, we find that increased levels of CREB activity lead to deficits in some forms of complex memory that involve fine spatial mapping and navigation. We conclude that a balanced level of CREB activity is a requisite for optimal learning.