We discover that an increase of neuronal excitability, triggered by enhanced activity of the transcription factor CREB, boosts simple forms of associative memory.
Year: 2009
Contrary to what would be expected of a molecular intermediary of memory formation, we find that increased levels of CREB activity lead to deficits in some forms of complex memory that involve fine spatial mapping and navigation. We conclude that a balanced level of CREB activity is a requisite for optimal learning.